Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 15/20 | 0.47 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.45 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.45 |
| ▸ | AKT1 | P31749 | 4/20 | 0.44 |
| ▸ | MTOR | P42345 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730694 | 0.75 | SFRP1 (0.63) | PIK3CASFRP1PIK3C3KDM4E | |
| SCHEMBL4637484 | 0.74 | SFRP1 (0.62) | PIK3CASFRP1KDM4ENAMPT | |
| SCHEMBL6101796 | 0.68 | SFRP1 (0.60) | SFRP1 | |
| SCHEMBL4636730 | 0.66 | HTR2A (0.41) | SFRP1 | |
| SCHEMBL4370841 | 0.65 | ALDH1A1 (0.71) | KDM4E | |
| SCHEMBL4638272 | 0.65 | SFRP1 (0.59) | SFRP1MTORKDM4ENAMPT | |
| SCHEMBL21469915 | 0.64 | PIK3CA (1.00) | PIK3CAPIK3C3AKT1MTOR | |
| SCHEMBL29922696 | 0.64 | PIK3CA (1.00) | PIK3CAPIK3C3AKT1MTOR | |
| SCHEMBL14903597 | 0.64 | CYP11B1 (0.60) | KDM4ECYP11B1CYP11B2 | |
| SCHEMBL8182389 | 0.64 | AOC3 (0.60) | KDM4ECYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | disclosed |