Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.38 |
| ▸ | PLA2G7 | Q13093 | 4/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4638189 | 0.77 | EPAS1 (0.39) | PLA2G7EPAS1ALOX5APFEN1NR1H3 | |
| SCHEMBL3924227 | 0.76 | HTR2A (0.46) | ARSCN9AEPAS1HTR2ASLC6A4 | |
| SCHEMBL4637450 | 0.75 | PTGS2 (0.42) | SCN9AEPAS1SLC6A4 | |
| SCHEMBL3924231 | 0.75 | AR (0.46) | ARSCN9AHTR2ASLC6A4KCNH2 | |
| SCHEMBL2065273 | 0.74 | SCN9A (0.43) | SCN9APLA2G7BRAF | |
| SCHEMBL1692003 | 0.72 | SLC6A4 (0.42) | ARHTR2ASLC6A4KCNH2 | |
| SCHEMBL1960234 | 0.71 | KIF11 (0.36) | NR1H3CCR2 | |
| SCHEMBL4638438 | 0.71 | PTGDR2 (0.45) | NR1H3CCR2 | |
| SCHEMBL1331610 | 0.69 | PTGDR2 (0.51) | — | |
| SCHEMBL10606643 | 0.69 | AR (0.46) | AREPAS1HTR2ASLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | claimed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | claimed |
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | disclosed |