Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 10/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.37 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.36 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | ESRRA | P11474 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1692003 | 0.76 | SLC6A4 (0.42) | ARSLC6A4HTR2AKCNH2 | |
| SCHEMBL2066970 | 0.72 | RXRA (0.47) | MRGPRX4 | |
| SCHEMBL27583555 | 0.72 | CYP1A2 (0.59) | — | |
| SCHEMBL952338 | 0.71 | AR (0.65) | ARMRGPRX4 | |
| SCHEMBL5656320 | 0.70 | AR (0.50) | ARSLC6A4CYP2D6SLC6A2NOS2 | |
| SCHEMBL25373566 | 0.69 | AR (0.46) | ARSLC6A4CYP2D6SLC6A2NOS2 | |
| SCHEMBL4672154 | 0.69 | EPAS1 (0.59) | — | |
| SCHEMBL29837271 | 0.68 | AR (0.47) | ARMRGPRX4 | |
| SCHEMBL384969 | 0.68 | AR (0.47) | ARMRGPRX4 | |
| SCHEMBL4638354 | 0.68 | EPAS1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | claimed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | claimed |
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | disclosed |