Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | PNLIP | P16233 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
| ▸ | ESRRA | P11474 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL586313 | 0.77 | NR3C1 (0.47) | SMN1; SMN2LMNAL3MBTL1EPAS1PTGER4 | |
| SCHEMBL365823 | 0.74 | MRGPRX4 (0.55) | SMN1; SMN2LMNAL3MBTL1MRGPRX4PNLIP | |
| SCHEMBL28928700 | 0.72 | HTR2A (0.40) | L3MBTL1SCN9AKDM4E | |
| SCHEMBL1651161 | 0.72 | SRD5A2 (0.52) | SMN1; SMN2LMNASRD5A2TTRKDM4E | |
| SCHEMBL8612482 | 0.70 | SRD5A2 (0.69) | SMN1; SMN2LMNASRD5A2KDM4EHSD17B1 | |
| SCHEMBL370483 | 0.70 | USP2 (0.49) | SMN1; SMN2LMNAL3MBTL1PNLIPSCN9A | |
| SCHEMBL5069651 | 0.69 | LTA4H (0.53) | SMN1; SMN2LMNATTRKDM4ELTA4H | |
| SCHEMBL9777083 | 0.68 | HPGD (0.59) | SMN1; SMN2LMNAL3MBTL1SRD5A2LTA4H | |
| SCHEMBL4637503 | 0.68 | EPAS1 (0.49) | SMN1; SMN2LMNAEPAS1 | |
| SCHEMBL27698516 | 0.67 | ESRRA (0.53) | SMN1; SMN2LMNAL3MBTL1PNLIPSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | claimed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | claimed |
| EP-1963259-A2 | SUBSTITUTED DIPHENYLETHERS, -AMINES, -SULFIDES AND -METHANES FOR THE TREATMENT OF RESPIRATORY DISEASE | AstraZeneca AB (SE) | 2008-09-03 | — | — | EP | disclosed |
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007068894-A2 | SUBSTITUTED DIPHENYLETHERS, -AMINES, -SULFIDES AND -METHANES FOR THE TREATMENT OF RESPIRATORY DISEASE | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | disclosed |