Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TBXAS1 | P24557 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6101965 | 0.94 | ALDH1A1 (0.57) | CYP19A1ALDH1A1KMT2APOLB | |
| SCHEMBL6102912 | 0.90 | ALDH1A1 (0.48) | CYP19A1ALDH1A1KMT2APOLB | |
| SCHEMBL4847556 | 0.87 | KMT2A (0.61) | CYP19A1ALDH1A1TBXAS1KMT2APOLB | |
| SCHEMBL4783295 | 0.86 | ALDH1A1 (0.44) | CYP19A1ALDH1A1KMT2APOLB | |
| SCHEMBL6102917 | 0.86 | CYP19A1 (0.50) | CYP19A1ALDH1A1TBXAS1KMT2APOLB | |
| SCHEMBL4637806 | 0.86 | ALDH1A1 (0.43) | CYP19A1ALDH1A1TBXAS1KMT2APOLB | |
| SCHEMBL4637410 | 0.85 | ALDH1A1 (0.58) | CYP19A1ALDH1A1KMT2APOLB | |
| SCHEMBL4638509 | 0.84 | CYP19A1 (0.56) | CYP19A1ALDH1A1KMT2APOLB | |
| SCHEMBL4637652 | 0.83 | WNT3 (0.51) | CYP19A1ALDH1A1TBXAS1KMT2APOLB | |
| SCHEMBL6102484 | 0.82 | ALDH1A1 (0.42) | CYP19A1ALDH1A1TBXAS1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | claimed |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | claimed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | claimed |
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | disclosed |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | disclosed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | SFRP1, SOS1, FZD7 | CYP19A1 1047/4885ALDH1A1 1865/4885TBXAS1 2485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.