Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 2/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637734 | 0.88 | CYP19A1 (0.46) | PTGER4CYP19A1ALDH1A1GRIN1GRIN2B | |
| SCHEMBL4638860 | 0.84 | CYP19A1 (0.46) | P2RX7CYP19A1ALDH1A1TSHRHPGD | |
| SCHEMBL4637975 | 0.84 | CYP19A1 (0.39) | PTGER4P2RX7CYP19A1ALDH1A1TSHR | |
| SCHEMBL4638551 | 0.83 | IDH1 (0.55) | PTGER4P2RX7CYP19A1ALDH1A1TSHR | |
| SCHEMBL4638668 | 0.82 | POLB (0.51) | PTGER4P2RX7CYP19A1ALDH1A1GRIN1 | |
| SCHEMBL4637742 | 0.82 | ALDH1A1 (0.52) | P2RX7CYP19A1ALDH1A1TSHRGRIN1 | |
| SCHEMBL4638905 | 0.81 | IDH1 (0.41) | PTGER4P2RX7CYP19A1ALDH1A1TSHR | |
| SCHEMBL27625194 | 0.75 | IDH1 (0.51) | PTGER4ALDH1A1IDH1HSD11B1NPC1 | |
| SCHEMBL4637958 | 0.75 | POLB (0.45) | ALDH1A1GRIN1GRIN2BHPGDIDH1 | |
| SCHEMBL4638903 | 0.75 | IDH1 (0.38) | PTGER4P2RX7ALDH1A1L3MBTL1IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501808-B1 | TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-07-02 | — | — | EP | disclosed |