Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.46 |
| ▸ | IDH1 | O75874 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637742 | 0.92 | ALDH1A1 (0.52) | POLBGRIN1GRIN2BIDH1ALDH1A1 | |
| SCHEMBL27606659 | 0.90 | POLB (0.49) | POLBGRIN1GRIN2BHTTL3MBTL1 | |
| SCHEMBL4638551 | 0.89 | IDH1 (0.55) | POLBPTGER4IDH1ALDH1A1GAA | |
| SCHEMBL4637730 | 0.88 | MAPT (0.50) | POLBGRIN1GRIN2BHTTL3MBTL1 | |
| SCHEMBL4639523 | 0.85 | MAPT (0.46) | POLBGRIN1GRIN2BHTTL3MBTL1 | |
| SCHEMBL4637958 | 0.85 | POLB (0.45) | POLBGRIN1GRIN2BIDH1ALDH1A1 | |
| SCHEMBL4637702 | 0.82 | PTGER4 (0.44) | GRIN1GRIN2BL3MBTL1PTGER4IDH1 | |
| N-Benzylmethylamine SCHEMBL5796449 | 0.82 | POLB (0.54) | POLBHTTL3MBTL1SMN1; SMN2PTGER4 | |
| SCHEMBL4637753 | 0.82 | IDH1 (0.47) | POLBGRIN1GRIN2BHTTL3MBTL1 | |
| SCHEMBL27625194 | 0.81 | IDH1 (0.51) | POLBPTGER4IDH1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501808-B1 | TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-07-02 | — | — | EP | disclosed |