Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.45 |
| ▸ | IDH1 | O75874 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637999 | 0.92 | IDH1 (0.46) | MAPTSMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL4638568 | 0.90 | IDH1 (0.54) | SMN1; SMN2KDM4ECYP19A1IDH1PTGER4 | |
| SCHEMBL4638668 | 0.88 | POLB (0.51) | MAPTSMN1; SMN2ALDH1A1POLBTP53 | |
| SCHEMBL4639523 | 0.87 | MAPT (0.46) | MAPTSMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL4637961 | 0.86 | CFTR (0.46) | SMN1; SMN2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL4637734 | 0.83 | CYP19A1 (0.46) | SMN1; SMN2ALDH1A1CYP19A1GRIN1GRIN2B | |
| SCHEMBL4637833 | 0.83 | CYP19A1 (0.59) | MAPTSMN1; SMN2KDM4EALDH1A1CYP19A1 | |
| SCHEMBL4637971 | 0.81 | CYP19A1 (0.50) | SMN1; SMN2ALDH1A1CYP19A1IDH1CYP1A2 | |
| SCHEMBL4707976 | 0.81 | CYP19A1 (0.57) | MAPTSMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL4637772 | 0.81 | IDH1 (0.51) | MAPTSMN1; SMN2MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501808-B1 | TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-07-02 | — | — | EP | disclosed |