Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.43 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.43 |
| ▸ | SFRP1 | Q8N474 | 5/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4615976 | 0.86 | SFRP1 (0.55) | CYP2C9NAMPTMEN1KMT2ACYP2C19 | |
| SCHEMBL4637732 | 0.83 | CYP2C9 (0.48) | CYP2C9NAMPTMEN1KMT2ACYP2C19 | |
| SCHEMBL4637000 | 0.75 | SFRP1 (0.56) | KMT2AALDH1A1SFRP1CA1CA2 | |
| SCHEMBL6101796 | 0.70 | SFRP1 (0.60) | SFRP1 | |
| SCHEMBL4616485 | 0.70 | SFRP1 (0.52) | LMNASLC12A2SLC12A5SFRP1CA12 | |
| SCHEMBL4637484 | 0.68 | SFRP1 (0.62) | NAMPTALDH1A1SFRP1KDM4E | |
| SCHEMBL4617728 | 0.68 | LMNA (0.60) | NAMPTLMNASFRP1 | |
| SCHEMBL4617999 | 0.68 | SFRP1 (0.52) | LMNASLC12A2SLC12A5SFRP1CA12 | |
| SCHEMBL4618553 | 0.66 | SFRP1 (0.59) | SFRP1 | |
| SCHEMBL2568189 | 0.66 | ALDH1A1 (0.55) | CYP2C9NAMPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | disclosed |