Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | PDE8B | O95263 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637794 | 0.94 | ALDH1A1 (0.36) | ALDH1A1TSHRADORA3KMT2AMEN1 | |
| SCHEMBL4637757 | 0.89 | ALDH1A1 (0.33) | ALDH1A1TSHRPDE8BIDH1P2RX7 | |
| SCHEMBL4639390 | 0.89 | GLS (0.35) | ALDH1A1TSHRIDH1KMT2AMEN1 | |
| SCHEMBL4639447 | 0.88 | IDH1 (0.35) | ALDH1A1TSHRPDE8BIDH1KMT2A | |
| SCHEMBL4637834 | 0.84 | ABL1 (0.33) | TSHRMAPK1MAPTHPGDLMNA | |
| SCHEMBL4638502 | 0.82 | CDK9 (0.34) | ALDH1A1TSHRPDE8BIDH1P2RX7 | |
| SCHEMBL4637728 | 0.82 | IDH1 (0.37) | ALDH1A1TSHRPDE8BIDH1P2RX7 | |
| SCHEMBL4638590 | 0.82 | ALDH1A1 (0.34) | ALDH1A1TSHRMETCYP19A1 | |
| SCHEMBL4638641 | 0.81 | IDH1 (0.41) | ALDH1A1TSHRPDE8BIDH1P2RX7 | |
| SCHEMBL4638099 | 0.80 | IDH1 (0.36) | ALDH1A1TSHRIDH1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501808-B1 | TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-07-02 | — | — | EP | disclosed |