Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 4/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | DDR1 | Q08345 | 12/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2065615 | 0.78 | PTGDR2 (0.47) | DDR1 | |
| SCHEMBL4877093 | 0.76 | DDR1 (0.48) | ARCCR2HTR2ASLC6A4KCNH2 | |
| SCHEMBL2394982 | 0.70 | PTGDR2 (0.44) | CCR2HTR2ASLC6A4KCNH2DDR1 | |
| SCHEMBL2395866 | 0.69 | CCR2 (0.41) | CCR2HTR2ASLC6A4KCNH2DDR1 | |
| SCHEMBL18184375 | 0.68 | DDR1 (0.45) | CCR2DDR1 | |
| SCHEMBL4637590 | 0.68 | PTGDR2 (0.46) | EPAS1 | |
| SCHEMBL4637463 | 0.68 | AR (0.42) | ARCCR2NR1H3HTR2ASLC6A4 | |
| SCHEMBL4639087 | 0.67 | EPAS1 (0.44) | HTR2ASLC6A4KCNH2EPAS1 | |
| SCHEMBL4194854 | 0.67 | DDR1 (0.46) | CCR2DDR1 | |
| SCHEMBL28354760 | 0.65 | MAOA (0.50) | ARHTR2ASLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | claimed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | claimed |
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | disclosed |