Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4638473 | 0.83 | ALDH1A1 (0.65) | POLBPTGER4SMN1; SMN2CYP19A1ALDH1A1 | |
| SCHEMBL4638668 | 0.82 | POLB (0.51) | POLBPTGER4SMN1; SMN2CYP19A1ALDH1A1 | |
| SCHEMBL6072189 | 0.80 | CYP19A1 (0.48) | POLBPTGER4SMN1; SMN2CYP19A1ALDH1A1 | |
| SCHEMBL4707735 | 0.79 | TACR1 (0.52) | PTGER4CYP19A1ALDH1A1GAATP53 | |
| SCHEMBL4707976 | 0.76 | CYP19A1 (0.57) | POLBSMN1; SMN2CYP19A1ALDH1A1GAA | |
| SCHEMBL9912521 | 0.76 | POLB (0.58) | POLBPTGER4ALDH1A1GAAAKR1C3 | |
| SCHEMBL4706776 | 0.76 | ALDH1A1 (0.54) | POLBPTGER4SMN1; SMN2CYP19A1ALDH1A1 | |
| SCHEMBL4637730 | 0.75 | MAPT (0.50) | POLBPTGER4SMN1; SMN2CYP19A1ALDH1A1 | |
| SCHEMBL6072058 | 0.75 | ALDH1A1 (0.53) | POLBPTGER4CYP19A1ALDH1A1GAA | |
| SCHEMBL4637749 | 0.75 | ALDH1A1 (0.53) | POLBSMN1; SMN2CYP19A1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638944-A1 | TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2005000821-A1 | TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-01-06 | — | — | WO | disclosed |