Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637896 | 0.74 | NPC1 (0.47) | NPC1RAB9AKMT2AMEN1L3MBTL1 | |
| SCHEMBL4638002 | 0.71 | NPC1 (0.40) | NPC1RAB9AKMT2AMEN1L3MBTL1 | |
| SCHEMBL4638835 | 0.69 | HSP90AA1 (0.38) | NPC1RAB9AL3MBTL1SMN1; SMN2TP53 | |
| SCHEMBL24598909 | 0.67 | GPBAR1 (0.48) | KMT2AGPBAR1ALDH1A1HTTLMNA | |
| SCHEMBL29692090 | 0.67 | GPBAR1 (0.48) | KMT2AGPBAR1ALDH1A1HTTLMNA | |
| SCHEMBL28318365 | 0.65 | HTR3A (0.43) | NPC1RAB9AKMT2AMEN1L3MBTL1 | |
| SCHEMBL21486108 | 0.65 | USP1 (0.42) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL30605725 | 0.64 | GPBAR1 (0.51) | KMT2AGPBAR1ALDH1A1HTTLMNA | |
| SCHEMBL24598908 | 0.64 | GPBAR1 (0.51) | KMT2AGPBAR1ALDH1A1HTTLMNA | |
| SCHEMBL21098177 | 0.64 | GPBAR1 (0.54) | NPC1KMT2AMEN1GPBAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501808-B1 | TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-07-02 | — | — | EP | disclosed |
| CN-1649849-A | Tachykinin receptor antagonists | LILLY CO ELI (US) | 2005-08-03 | — | — | CN | disclosed |