SCHEMBL4639401

SCHEMBL4639401

Cc1nc(N)c(C)c(C)c1C

nearest known ligand 0.48

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.48
IDO1 P14902 3/20 0.43
HTT P42858 2/20 0.34
HSD17B10 Q99714 2/20 0.34
ADRA2A P08913 1/20 0.34
ADORA2A P29274 1/20 0.34
KDM4E B2RXH2 4/20 0.33
ALDH1A1 P00352 3/20 0.33
GAA P10253 1/20 0.33
HPGD P15428 1/20 0.33
CDC7 O00311 1/20 0.33
DBF4 Q9UBU7 1/20 0.33
PDE10A Q9Y233 1/20 0.32
NOS1 P29475 2/20 0.32
NOS3 P29474 1/20 0.31
NOS2 P35228 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2067816 0.85 LMNA (0.46) LMNAIDO1HTTHSD17B10ADRA2A
SCHEMBL29668443 0.85 LMNA (0.46) LMNAIDO1HTTHSD17B10ADRA2A
SCHEMBL3670530 0.83 LMNA (0.41) LMNAIDO1KDM4EALDH1A1PDE10A
Hydrochloric Acid SCHEMBL4932899 0.82 LMNA (0.44) LMNAIDO1HTTHSD17B10ADRA2A
SCHEMBL3668788 0.81 LMNA (0.48) LMNAIDO1HTTHSD17B10ADRA2A
SCHEMBL29668501 0.79 LMNA (0.46) LMNAIDO1HTTHSD17B10ADRA2A
SCHEMBL2284408 0.79 LMNA (0.46) LMNAIDO1HTTHSD17B10ADRA2A
SCHEMBL31128244 0.77 LMNA (0.71) LMNAIDO1HTTHSD17B10ADRA2A
SCHEMBL77010 0.75 IDO1 (0.35) LMNAIDO1
SCHEMBL23170360 0.75 IDO1 (0.50) LMNAIDO1HTTHSD17B10ADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103275160-A Chemical synthetic method of low affinity ligand of oxidized low density lipoprotein receptor CD36 UNIV DALIAN 2013-09-04 CN claimed
US-20240067646-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY HOFFMANN-LA ROCHE INC. 2024-02-29 US disclosed
CN-117024615-A Preparation method and application of algal polysaccharide derivative 马强 2023-11-10 CN disclosed
US-11753407-B2 Compounds for treating spinal muscular atrophy PTC THERAPEUTICS, INC. (US) 2023-09-12 US disclosed
WO-2019194556-A1 NOVEL 6-HETEROARYLAMINO-2,4,5-TRIMETHYLPYRIDIN-3-OL COMPOUND, OR PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING INFLAMMATORY BOWEL DISEASES AND AUTOIMMUNE DISEASES COMPRISING SAME 영남대학교 산학협력단 2019-10-10 WO disclosed
WO-2018131924-A1 PYRIDINOL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING AUTOIMMUNE DISEASES, CONTAINING SAME AS ACTIVE INGREDIENT 영남대학교 산학협력단 2018-07-19 WO disclosed
CN-108084528-A A kind of rubber material and preparation method 航天特种材料及工艺技术研究所 2018-05-29 CN disclosed
US-20180105526-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY PTC THERAPEUTICS INC (US) 2018-04-19 US disclosed
US-9879007-B2 Compounds for treating spinal muscular atrophy PTC THERAPEUTICS, INC. (US) 2018-01-30 US disclosed
WO-2017123038-A1 PYRIDINOL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT 영남대학교 산학협력단 2017-07-20 WO disclosed
US-20130178631-A1 NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS ADDEX PHARMA SA (CH) 2013-07-11 US disclosed
US-20120277237-A1 NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS ADDEX PHARMA SA (CH) 2012-11-01 US disclosed
US-20120232072-A1 IMIDAZOPYRIDINE DERIVATIVES PIRAMAL LIFE SCIENCES LIMITED (IN) 2012-09-13 US disclosed
US-8101637-B2 Alkynyl derivatives as modulators of metatropic glutamate receptors ADDEX PHARMA SA (CH) 2012-01-24 US disclosed
CN-101166729-B Fused heterocyclic compounds TAKAEDA CHEMICAL IND LTD 2011-08-31 CN disclosed
US-20090124625-A1 NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METATROPIC GLUTAMATE RECEPTORS ADDEX PHARMACEUTICALS SA (CH) 2009-05-14 US disclosed
EP-1874736-A4 FUSED HETEROCYCLIC COMPOUNDS TAKEDA PHARMACEUTICAL (JP) 2008-08-20 EP disclosed
CN-101166729-A Fused heterocyclic compounds TAKEDA PHARMACEUTICAL (JP) 2008-04-23 CN disclosed
EP-1874736-A2 FUSED HETEROCYCLIC COMPOUNDS Takeda Pharmaceutical Company Limited (JP) 2008-01-09 EP disclosed
WO-2006116412-A2 FUSED HETEROCYCLIC COMPOUNDS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2006-11-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240067646-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY SMN1; SMN2, CPT1B, GYS1 LMNA 235/4885IDO1 4746/4885HTT 755/4885
US-20130178631-A1 NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS GRM5, GRM1, GRM2 LMNA 4407/4885IDO1 3816/4885HTT 932/4885
US-20090124625-A1 NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METATROPIC GLUTAMATE RECEPTORS GRM5, GRM2, GRM1 LMNA 4715/4885IDO1 2868/4885HTT 910/4885
US-20180105526-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY SMN1; SMN2, CPT1B, GYS1 LMNA 178/4885IDO1 4782/4885HTT 264/4885
US-20120277237-A1 NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS GRM5, GRM1, GRM2 LMNA 4407/4885IDO1 3816/4885HTT 932/4885
US-20120232072-A1 IMIDAZOPYRIDINE DERIVATIVES IL6, IL6ST, STAT3 LMNA 4132/4885IDO1 2662/4885HTT 3672/4885
US-11753407-B2 Compounds for treating spinal muscular atrophy SMN1; SMN2, CPT1B, GYS1 LMNA 166/4885IDO1 4687/4885HTT 577/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.