Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 9/20 | 0.48 |
| ▸ | ITGAV | P06756 | 9/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4640271 | 1.00 | ITGB3 (0.48) | ITGB3ITGAVADORA1BTKHRH1 | |
| SCHEMBL4640963 | 0.91 | ITGB3 (0.46) | ITGB3ITGAVADORA1HRH1 | |
| SCHEMBL4640954 | 0.91 | ITGB3 (0.46) | ITGB3ITGAVADORA1HRH1 | |
| SCHEMBL6810232 | 0.88 | ITGB3 (0.46) | ITGB3ITGAVADORA1BTK | |
| SCHEMBL6810237 | 0.88 | ITGB3 (0.46) | ITGB3ITGAVADORA1BTK | |
| SCHEMBL6805719 | 0.83 | BTK (0.42) | ITGB3ITGAVADORA1BTK | |
| SCHEMBL4644200 | 0.83 | BTK (0.42) | ITGB3ITGAVADORA1BTK | |
| SCHEMBL6806539 | 0.82 | BTK (0.43) | ADORA1BTKFLT3 | |
| SCHEMBL5840142 | 0.80 | HDAC6 (0.47) | ITGB3ITGAV | |
| SCHEMBL4640793 | 0.79 | ITGB3 (0.47) | ITGB3ITGAVADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0853084-B1 | Substituted purine derivatives as vitronectin receptor antagonists | HOECHST AG (DE) | 2008-08-13 | — | — | EP | disclosed |
| US-6723727-B1 | VITRONECTIN RECEPTOR ANTAGONISTS; INHIBITORS OF BONE RESORPTION; OSTEOPOROSIS | HOECHST AKTIENGESELLSCHAFT (DE) | 2004-04-20 | — | — | US | disclosed |
| EP-0853084-A2 | Substituted purine derivatives as vitronectin receptor antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-07-15 | — | — | EP | disclosed |