Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4640806 | 0.69 | POLB (0.36) | TP53POLBKDM4EMAPTGAA | |
| SCHEMBL21608049 | 0.67 | SMN1; SMN2 (0.41) | SMN1; SMN2HSD17B10KDM4EMAPTL3MBTL1 | |
| SCHEMBL2975617 | 0.66 | ADORA3 (0.45) | SMN1; SMN2MAPTL3MBTL1MEN1KMT2A | |
| SCHEMBL22135199 | 0.64 | ALDH1A1 (0.35) | TP53SMN1; SMN2HSD17B10POLBKDM4E | |
| SCHEMBL24329592 | 0.62 | MEN1 (0.51) | TP53SMN1; SMN2HSD17B10POLBKDM4E | |
| SCHEMBL130860 | 0.62 | KDM4E (0.57) | SMN1; SMN2HSD17B10POLBKDM4EMAPT | |
| SCHEMBL2175321 | 0.62 | RAB9A (0.69) | TP53SMN1; SMN2HSD17B10POLBKDM4E | |
| SCHEMBL9556044 | 0.62 | MEN1 (0.47) | SMN1; SMN2HSD17B10POLBKDM4EMAPT | |
| SCHEMBL14247557 | 0.61 | NPC1 (0.50) | SMN1; SMN2HSD17B10POLBKDM4EMAPT | |
| SCHEMBL25171869 | 0.61 | DYRK1A (0.50) | TP53SMN1; SMN2HSD17B10POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318985-A1 | Novel 2-Aminopyrimidinone Or 2-Aminopyridinone Derivatives and Their Use | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
| US-20080318985-A1 | Novel 2-Aminopyrimidinone Or 2-Aminopyridinone Derivatives and Their Use | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
| US-20080318985-A1 | Novel 2-Aminopyrimidinone Or 2-Aminopyridinone Derivatives and Their Use | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
| EP-1951682-A1 | NOVEL 2-AMINOPYRIMIDINONE OR 2-AMINOPYRIDINONE DERIVATIVES AND THEIR USE | Astra Zeneca AB (SE) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007058582-A1 | NOVEL 2-AMINOPYRIMIDINONE OR 2-AMINOPYRIDINONE DERIVATIVES AND THEIR USE | ASTRAZENECA AB (SE) | 2007-05-24 | — | — | WO | disclosed |
| WO-2007058582-A1 | NOVEL 2-AMINOPYRIMIDINONE OR 2-AMINOPYRIDINONE DERIVATIVES AND THEIR USE | ASTRAZENECA AB (SE) | 2007-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318985-A1 | Novel 2-Aminopyrimidinone Or 2-Aminopyridinone Derivatives and Their Use | PSEN2, PSEN1, GRIN2D | TP53 1412/4885SMN1; SMN2 140/4885HSD17B10 1274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.