Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 9/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5605482 | 0.75 | ENPP2 (0.42) | KDM1APTGS2ENPP2PTGS1CNR2 | |
| SCHEMBL8198598 | 0.68 | ENPP2 (0.45) | KDM1APTGS2ENPP2PTGS1 | |
| SCHEMBL1604341 | 0.64 | PNMT (0.52) | KDM1APTGS2ENPP2PTGS1SLC6A2 | |
| SCHEMBL2376239 | 0.63 | ENPP2 (0.72) | PTGS2ENPP2 | |
| SCHEMBL15212423 | 0.63 | KDM1A (0.60) | KDM1ASLC6A2SLC6A3 | |
| SCHEMBL2666156 | 0.62 | ENPP2 (0.44) | PTGS2ENPP2PTGS1HSD11B1 | |
| SCHEMBL17987982 | 0.61 | KDM1A (1.00) | KDM1A | |
| SCHEMBL1604392 | 0.60 | DGAT1 (0.45) | PTGS2ENPP2PTGS1CNR2 | |
| SCHEMBL15385491 | 0.60 | CYP2C19 (0.49) | ENPP2KMT2A | |
| SCHEMBL13784388 | 0.60 | ENPP2 (0.37) | PTGS2ENPP2PTGS1HSD11B1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951696-A2 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | Amgen Inc. (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007061661-A2 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | AMGEN INC. (US) | 2007-05-31 | — | — | WO | disclosed |