Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 13/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1604341 | 0.79 | PNMT (0.52) | ENPP2PTGS2PTGS1KDM1A | |
| SCHEMBL1604392 | 0.75 | DGAT1 (0.45) | ENPP2PTGS2PTGS1CNR2 | |
| SCHEMBL4640563 | 0.75 | KDM1A (0.43) | ENPP2PTGS2PTGS1KMT2ACNR2 | |
| SCHEMBL31532534 | 0.73 | ENPP2 (0.35) | ENPP2PTGS2PTGS1 | |
| SCHEMBL8198598 | 0.72 | ENPP2 (0.45) | ENPP2PTGS2PTGS1KDM1A | |
| SCHEMBL1605275 | 0.72 | ENPP2 (0.38) | ENPP2PTGS2PTGS1KMT2ACNR2 | |
| SCHEMBL12759864 | 0.72 | CYP3A4 (0.39) | ENPP2PTGS2PTGS1KMT2A | |
| SCHEMBL2376239 | 0.71 | ENPP2 (0.72) | ENPP2PTGS2 | |
| SCHEMBL13784388 | 0.71 | ENPP2 (0.37) | ENPP2PTGS2PTGS1KMT2A | |
| SCHEMBL1605170 | 0.70 | ALDH1A1 (0.43) | ENPP2PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753736-A2 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | Amgen Inc. (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005116002-A2 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | AMGEN INC. (US) | 2005-12-08 | — | — | WO | disclosed |