Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4887236 | 0.76 | KDM4E (0.53) | KDM4ELMNASMN1; SMN2EPHX2NR1H4 | |
| Trifluoroacetic Acid SCHEMBL5315234 | 0.76 | ALDH1A1 (0.45) | SMN1; SMN2ALDH1A1KMT2A | |
| Trifluoroacetic Acid SCHEMBL2480625 | 0.74 | HTR6 (0.55) | SMN1; SMN2ADRA2CADRA1AADRA1BDRD2 | |
| SCHEMBL3778179 | 0.72 | ADRA2C (0.47) | KDM4ELMNAMAPTSMN1; SMN2CYP17A1 | |
| SCHEMBL5359155 | 0.72 | ALDH1A1 (0.53) | KDM4ELMNAMAPTSMN1; SMN2CYP17A1 | |
| SCHEMBL3788443 | 0.71 | ADRA2C (0.56) | KDM4ELMNASMN1; SMN2EPHX2NR1H4 | |
| SCHEMBL12970664 | 0.71 | MEN1 (0.52) | LMNASMN1; SMN2CYP17A1CYP1A2CYP2C9 | |
| SCHEMBL12017964 | 0.70 | SMN1; SMN2 (0.67) | LMNASMN1; SMN2CYP17A1CYP1A2CYP2C9 | |
| Hydrochloric Acid SCHEMBL3778982 | 0.70 | ADRA2C (0.55) | KDM4ELMNAMAPTSMN1; SMN2EPHX2 | |
| SCHEMBL11570669 | 0.70 | KMT2A (0.49) | KDM4ELMNAMAPTSMN1; SMN2CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824837-B1 | SUBSTITUTED N-SULFONYLAMINOBENZYL-2-PHENOXY ACETAMIDE COMPOUNDS | PFIZER (US) | 2008-08-13 | — | — | EP | disclosed |
| US-7214824-B2 | Substituted N-sulfonylaminobenzyl-2-phenoxyacetamide compounds as VR1 receptor agonists | PFIZER INC. (US) | 2007-05-08 | — | — | US | disclosed |
| US-20060100460-A1 | Substituted N-sulfonylaminobenzyl-2-phenoxyacetamide compounds as VR1 receptor agonists | PFIZER, INC. | 2006-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100460-A1 | Substituted N-sulfonylaminobenzyl-2-phenoxyacetamide compounds as VR1 receptor agonists | CNR1, AVPR1A, OPRL1 | KDM4E 4801/4885LMNA 2299/4885MAPT 4719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.