Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.41 |
| ▸ | KDM1A | O60341 | 4/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | PRKX | P51817 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15677943 | 0.83 | KMT2A (0.53) | ALDH1A1HDAC1HDAC6MMP13HDAC3 | |
| SCHEMBL27823146 | 0.83 | RECQL (0.69) | CYP2C9CYP2C19RECQLLMNAMMP13 | |
| SCHEMBL27824293 | 0.82 | RECQL (0.62) | CYP2C9CYP2C19RECQLDYRK1ACLK4 | |
| SCHEMBL1124145 | 0.80 | TGM2 (0.58) | LMNAALDH1A1HDAC1KDM1AHDAC6 | |
| SCHEMBL25546132 | 0.79 | TPSAB1 (0.63) | CYP2C9CYP2C19RECQLLMNAALDH1A1 | |
| SCHEMBL8245493 | 0.79 | LMNA (0.64) | CYP2C9CYP2C19RECQLLMNAALDH1A1 | |
| SCHEMBL17080177 | 0.78 | FFAR1 (0.44) | LMNAALDH1A1HDAC1MAP4K4DYRK1A | |
| SCHEMBL4642962 | 0.77 | CHRM4 (0.53) | CYP2C9CYP2C19RECQLALDH1A1HDAC1 | |
| SCHEMBL31258400 | 0.76 | ROCK2 (0.60) | CYP2C9CYP2C19ROCK2ROCK1 | |
| SCHEMBL23451014 | 0.75 | CYP2C9 (0.56) | CYP2C9CYP2C19RECQLLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663204-A4 | C-KIT MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2008-08-13 | — | — | EP | disclosed |
| EP-1663204-A2 | C-KIT MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005020921-A2 | C-KIT MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2005-03-10 | — | — | WO | disclosed |