Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4647290 | 0.92 | MAPT (0.39) | CHRM3MAPTTHRBLMNAPOLB | |
| SCHEMBL4643018 | 0.91 | MAPT (0.39) | CHRM3MAPTTHRBLMNAPOLB | |
| SCHEMBL13054237 | 0.88 | POLB (0.48) | MAPTTHRBLMNAPOLBTP53 | |
| SCHEMBL4641230 | 0.87 | PTGDR2 (0.42) | MAPTTHRBLMNAPOLBTDP1 | |
| SCHEMBL4645865 | 0.86 | PTGDR2 (0.41) | MAPTTHRBLMNAPOLBTDP1 | |
| SCHEMBL4641495 | 0.86 | MAPT (0.39) | MAPTTHRBLMNAPOLBTDP1 | |
| SCHEMBL4641465 | 0.85 | KMT2A (0.41) | MAPTTHRBLMNAPOLBTDP1 | |
| SCHEMBL4641475 | 0.83 | MAPT (0.45) | MAPTTHRBLMNAPOLBTDP1 | |
| SCHEMBL4643445 | 0.83 | RAB9A (0.46) | MAPTTHRBLMNAPOLBTDP1 | |
| SCHEMBL3743861 | 0.82 | MCHR1 (0.45) | MAPTPOLBKMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-B1 | NOVEL MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-13 | — | — | EP | claimed |