Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | EBP | Q15125 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HTR1F | P30939 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4645865 | 0.95 | PTGDR2 (0.41) | PTGDR2KMT2AHCRTR1HCRTR2MAPT | |
| SCHEMBL4641465 | 0.95 | KMT2A (0.41) | PTGDR2KMT2AMCHR1HCRTR1HCRTR2 | |
| SCHEMBL13054240 | 0.88 | HTR1F (0.49) | PTGDR2MCHR1MAPTTHRBLMNA | |
| SCHEMBL4641189 | 0.87 | CHRM3 (0.41) | KMT2AMAPTTHRBLMNAPOLB | |
| SCHEMBL4643538 | 0.86 | MCHR1 (0.41) | KMT2AMCHR1MAPTPOLBTDP1 | |
| SCHEMBL13054193 | 0.83 | POLB (0.48) | PTGDR2MCHR1HCRTR1HCRTR2MAPT | |
| SCHEMBL5248402 | 0.82 | HTR1F (0.52) | MCHR1MAPTTHRBLMNAPOLB | |
| SCHEMBL4647290 | 0.81 | MAPT (0.39) | KMT2AMAPTTHRBLMNAPOLB | |
| SCHEMBL4643018 | 0.80 | MAPT (0.39) | KMT2AMAPTTHRBLMNAPOLB | |
| SCHEMBL4641475 | 0.80 | MAPT (0.45) | KMT2AMCHR1MAPTTHRBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-B1 | NOVEL MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-13 | — | — | EP | claimed |