Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.40 |
| ▸ | NTMT1 | Q9BV86 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4641230 | 0.95 | PTGDR2 (0.42) | PTGDR2HCRTR1HCRTR2KMT2AMAPT | |
| SCHEMBL4641465 | 0.90 | KMT2A (0.41) | PTGDR2HCRTR1HCRTR2KMT2AMAPT | |
| SCHEMBL13054193 | 0.88 | POLB (0.48) | PTGDR2HCRTR1HCRTR2MAPTPOLB | |
| SCHEMBL4641189 | 0.86 | CHRM3 (0.41) | KMT2AMAPTPOLBTHRBLMNA | |
| SCHEMBL13054240 | 0.83 | HTR1F (0.49) | PTGDR2MAPTPOLBTHRBLMNA | |
| SCHEMBL4643538 | 0.81 | MCHR1 (0.41) | KCNH2KMT2AMAPTPOLBTDP1 | |
| SCHEMBL4643115 | 0.81 | PTGDR2 (0.43) | PTGDR2KCNH2MALT1MAPTPOLB | |
| SCHEMBL4647290 | 0.81 | MAPT (0.39) | KMT2AMAPTPOLBTHRBLMNA | |
| SCHEMBL4643018 | 0.80 | MAPT (0.39) | KCNH2KMT2AMAPTPOLBTHRB | |
| SCHEMBL4641475 | 0.80 | MAPT (0.45) | KMT2AMAPTPOLBTHRBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-B1 | NOVEL MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-13 | — | — | EP | claimed |