Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 8/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5293870 | 0.91 | MAPT (0.44) | MCHR1MAPTMEN1KMT2ATP53 | |
| SCHEMBL4641230 | 0.86 | PTGDR2 (0.42) | MCHR1MAPTKMT2ATDP1TP53 | |
| SCHEMBL4645865 | 0.81 | PTGDR2 (0.41) | MAPTKMT2ATDP1KCNH2TP53 | |
| SCHEMBL4641465 | 0.81 | KMT2A (0.41) | MCHR1MAPTKMT2ATDP1TP53 | |
| SCHEMBL4641406 | 0.80 | MAPT (0.42) | MCHR1MAPTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4641189 | 0.74 | CHRM3 (0.41) | MAPTKMT2ATDP1TP53POLB | |
| SCHEMBL13054240 | 0.74 | HTR1F (0.49) | MCHR1MAPTTP53POLB | |
| SCHEMBL4643578 | 0.73 | MCHR1 (0.44) | MCHR1MAPTSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL4641593 | 0.72 | MAPT (0.46) | MCHR1MAPTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4647202 | 0.72 | CACNA1B (0.44) | MCHR1MAPTSMN1; SMN2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-B1 | NOVEL MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-13 | — | — | EP | claimed |