Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | S100A4 | P26447 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SGK1 | O00141 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2674701 | 0.85 | CYP1A2 (0.51) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL6229323 | 0.85 | TTR (0.52) | SMN1; SMN2NPC1RAB9AALDH1A1MAPK1 | |
| SCHEMBL14176467 | 0.83 | MAPT (0.61) | MAPTSMN1; SMN2S100A4NPC1RAB9A | |
| SCHEMBL24959804 | 0.82 | ALDH1A1 (0.45) | MAPTSMN1; SMN2ALDH1A1MAPK1EGFR | |
| SCHEMBL5608472 | 0.80 | HSD17B1 (0.62) | MAPTSMN1; SMN2S100A4NPC1RAB9A | |
| SCHEMBL7521709 | 0.80 | MAPT (0.68) | MAPTSMN1; SMN2S100A4NPC1RAB9A | |
| SCHEMBL8490253 | 0.79 | GSK3B (0.47) | ALDH1A1MAPK1KMT2AMEN1EGFR | |
| SCHEMBL25660885 | 0.79 | GSK3B (0.42) | — | |
| SCHEMBL11543441 | 0.79 | HSD17B1 (0.51) | MAPTSMN1; SMN2S100A4NPC1RAB9A | |
| SCHEMBL3800105 | 0.79 | MAPT (0.55) | MAPTSMN1; SMN2S100A4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951692-A1 | OXAZOLE AND THIAZOLE PPAR MODULATOR | IRM LLC (BM) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007056496-A1 | OXAZOLE AND THIAZOLE PPAR MODULATOR | IRM LLC (BM) | 2007-05-18 | — | — | WO | disclosed |