Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.45 |
| ▸ | TP53 | P04637 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CETP | P11597 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4641580 | 0.89 | MAPT (0.48) | MAPTTP53KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL5248381 | 0.87 | MAPT (0.58) | MAPTTP53KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL4641261 | 0.83 | KDM4E (0.44) | MAPTTP53KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL4641319 | 0.82 | MAPT (0.42) | MAPTTP53KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL4643568 | 0.81 | MCHR1 (0.47) | MAPTTP53KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL4641303 | 0.80 | TMPRSS15 (0.44) | MAPTTP53SMN1; SMN2ALDH1A1FAAH | |
| SCHEMBL4643537 | 0.78 | MAPT (0.42) | MAPTTP53KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL4643630 | 0.77 | MAPT (0.41) | MAPTTP53KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL4646624 | 0.76 | MAPT (0.42) | MAPTTP53KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL4641350 | 0.75 | MAPT (0.42) | MAPTTP53KDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-B1 | NOVEL MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-13 | — | — | EP | claimed |