Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TMPRSS15 | P98073 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4643038 | 0.92 | MCHR1 (0.48) | MAPTMEN1KMT2ATMPRSS15MCHR1 | |
| SCHEMBL4641593 | 0.92 | MAPT (0.46) | MAPTMEN1KMT2ATMPRSS15TP53 | |
| SCHEMBL4644016 | 0.92 | ALDH1A1 (0.43) | MAPTKMT2ATMPRSS15TP53LMNA | |
| SCHEMBL4647199 | 0.91 | MCHR1 (0.46) | MAPTTMPRSS15LMNAMCHR1 | |
| SCHEMBL5252975 | 0.87 | MCHR1 (0.51) | MAPTMEN1KMT2ATP53LMNA | |
| SCHEMBL4643578 | 0.86 | MCHR1 (0.44) | MAPTMEN1KMT2ATMPRSS15MCHR1 | |
| SCHEMBL4641355 | 0.86 | ALDH1A1 (0.44) | MAPTMEN1KMT2ATMPRSS15TP53 | |
| SCHEMBL4641244 | 0.85 | ALDH1A1 (0.45) | MAPTKMT2ATMPRSS15TP53LMNA | |
| SCHEMBL4641406 | 0.85 | MAPT (0.42) | MAPTMEN1KMT2ATMPRSS15LMNA | |
| SCHEMBL4643026 | 0.85 | MCHR1 (0.42) | MAPTMEN1KMT2ATMPRSS15LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-B1 | NOVEL MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-13 | — | — | EP | claimed |