Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | TMPRSS15 | P98073 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4644016 | 0.93 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2HTTKMT2ATMPRSS15 | |
| SCHEMBL4643663 | 0.92 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2HTTKMT2ATMPRSS15 | |
| SCHEMBL4641244 | 0.91 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2HTTKMT2ATMPRSS15 | |
| SCHEMBL4641601 | 0.86 | MAPT (0.43) | SMN1; SMN2KMT2ATMPRSS15MAPTLMNA | |
| SCHEMBL4643578 | 0.85 | MCHR1 (0.44) | ALDH1A1SMN1; SMN2HTTKMT2ATMPRSS15 | |
| SCHEMBL4643038 | 0.85 | MCHR1 (0.48) | ALDH1A1SMN1; SMN2HTTKMT2ATMPRSS15 | |
| SCHEMBL4647199 | 0.85 | MCHR1 (0.46) | TMPRSS15MAPTLMNA | |
| SCHEMBL4641406 | 0.84 | MAPT (0.42) | ALDH1A1SMN1; SMN2HTTKMT2ATMPRSS15 | |
| SCHEMBL4641593 | 0.84 | MAPT (0.46) | ALDH1A1SMN1; SMN2KMT2ATMPRSS15MAPT | |
| SCHEMBL4643026 | 0.84 | MCHR1 (0.42) | SMN1; SMN2KMT2ATMPRSS15MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-B1 | NOVEL MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-13 | — | — | EP | claimed |