Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGPAT2 | O15120 | 1/20 | 0.42 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | UTRN | P46939 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4646624 | 0.92 | MAPT (0.42) | ALDH1A1KDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL4645627 | 0.90 | ALDH1A1 (0.41) | AGPAT2PORCNALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL4641201 | 0.87 | AGPAT2 (0.42) | AGPAT2ALDH1A1KDM4EPOLBNPC1 | |
| SCHEMBL5248620 | 0.87 | MAPT (0.48) | ALDH1A1KDM4ESMN1; SMN2POLBNPSR1 | |
| SCHEMBL4643611 | 0.87 | SMN1; SMN2 (0.39) | AGPAT2ALDH1A1KDM4ESMN1; SMN2POLB | |
| SCHEMBL4641410 | 0.86 | AGPAT2 (0.42) | AGPAT2ALDH1A1KDM4EPOLBNPC1 | |
| SCHEMBL4643048 | 0.86 | AGPAT2 (0.42) | AGPAT2POLBMAPTTP53THRB | |
| SCHEMBL4641368 | 0.86 | PTGDR2 (0.40) | POLBMAPTTP53MCHR1THRB | |
| SCHEMBL4643098 | 0.86 | MAPT (0.46) | AGPAT2ALDH1A1KDM4ESMN1; SMN2POLB | |
| SCHEMBL4641302 | 0.83 | MAPT (0.42) | ALDH1A1KDM4ESMN1; SMN2POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-B1 | NOVEL MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-13 | — | — | EP | claimed |