SCHEMBL4644028

SCHEMBL4644028

[CH2]C(=O)Oc1ccc(OC(F)(F)F)cc1C=O

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 1/20 0.37
PIM1 P11309 1/20 0.37
SLC6A2 P23975 2/20 0.36
SLC6A4 P31645 2/20 0.36
GAA P10253 3/20 0.36
ALDH1A1 P00352 2/20 0.36
POLB P06746 1/20 0.36
THRB P10828 1/20 0.36
TGM2 P21980 1/20 0.35
DYRK1A Q13627 1/20 0.35
GPR3 P46089 1/20 0.35
KMT2A Q03164 2/20 0.35
MRGPRX4 Q96LA9 1/20 0.34
ERN1 O75460 1/20 0.34
KDM4E B2RXH2 2/20 0.34
AURKA O14965 1/20 0.34
TPX2 Q9ULW0 1/20 0.34
RAB9A P51151 1/20 0.34
MAOB P27338 1/20 0.34
ALPL P05186 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4645031 0.85 KDM4E (0.37) EPHX2PIM1SLC6A2SLC6A4GAA
SCHEMBL4641911 0.83 KDM4E (0.38) EPHX2PIM1SLC6A2SLC6A4GAA
SCHEMBL6500895 0.82 GPR3 (0.42) EPHX2PIM1SLC6A2GAAALDH1A1
SCHEMBL4645692 0.82 KDM4E (0.36) EPHX2PIM1SLC6A2SLC6A4GAA
SCHEMBL4642511 0.82 MRGPRX4 (0.37) EPHX2PIM1SLC6A2SLC6A4GAA
SCHEMBL4645690 0.81 TOP2A (0.39) EPHX2PIM1SLC6A2SLC6A4GAA
SCHEMBL4641889 0.81 FFAR1 (0.37) EPHX2PIM1SLC6A2SLC6A4GAA
SCHEMBL4645139 0.80 KMT2A (0.43) POLBKMT2AMRGPRX4KDM4ERAB9A
SCHEMBL4644515 0.80 ALDH1A1 (0.57) ALDH1A1KMT2AERN1KDM4ERAB9A
SCHEMBL4647390 0.79 KMT2A (0.40) ALDH1A1POLBKMT2AMRGPRX4KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1487928-B1 FILM-FORMING POLYMER AND ANTIFOULING PAINT JOTUN AS (NO) 2008-08-13 EP disclosed
EP-1487928-A1 FILM-FORMING POLYMER AND ANTIFOULING PAINT Jotun AS (NO) 2004-12-22 EP disclosed
WO-2003080747-A1 FILM-FORMING POLYMER AND ANTIFOULING PAINT JOTUN AS (NO) 2003-10-02 WO disclosed