Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6404875 | 0.82 | ADORA2B (0.46) | GAAADORA2BPOLBHSD17B10TSHR | |
| SCHEMBL4646681 | 0.82 | GAA (0.51) | GAAADORA2BPOLBHSD17B10KIF11 | |
| SCHEMBL4648748 | 0.81 | USP2 (0.43) | GAAPOLBHSD17B10KIF11TSHR | |
| SCHEMBL4646772 | 0.73 | TSHR (0.59) | GAAADORA2BTSHRRAB9A | |
| SCHEMBL4649112 | 0.72 | GAA (0.78) | GAAPOLBHSD17B10TSHRRAB9A | |
| SCHEMBL4648514 | 0.70 | GAA (0.58) | GAAHSD17B10TSHRRAB9A | |
| SCHEMBL6405985 | 0.67 | GAA (0.49) | GAAADORA2BHSD17B10TSHRRAB9A | |
| SCHEMBL3399033 | 0.66 | KIF11 (0.79) | GAAHSD17B10KIF11TSHR | |
| SCHEMBL24624782 | 0.65 | MAPK1 (0.68) | GAAADORA2BPOLBHSD17B10KIF11 | |
| SCHEMBL4648207 | 0.64 | USP2 (0.46) | GAAHSD17B10KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675834-A4 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2008-08-27 | — | — | EP | disclosed |
| EP-1675834-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005037799-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2005-04-28 | — | — | WO | disclosed |