Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 7/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | GRK5 | P34947 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38209 | 0.89 | GSK3B (0.43) | FYNHDAC4HDAC1HDAC6CAMK2D | |
| SCHEMBL45068 | 0.82 | HPGD (0.38) | FYNHDAC4HDAC1HDAC6CAMK2D | |
| SCHEMBL994121 | 0.81 | LMNA (0.46) | MAP4K4RAD52 | |
| SCHEMBL44476 | 0.79 | GAA (0.37) | FYNHDAC4GAASYK | |
| SCHEMBL44764 | 0.79 | GAA (0.44) | GSK3BGAA | |
| SCHEMBL43893 | 0.78 | GSK3B (0.44) | HDAC4HDAC6GSK3BGAA | |
| SCHEMBL43831 | 0.78 | GAA (0.43) | GSK3BGAA | |
| SCHEMBL43913 | 0.77 | GAA (0.43) | GSK3BGAASYK | |
| SCHEMBL44713 | 0.77 | ALDH1A1 (0.42) | — | |
| SCHEMBL44578 | 0.77 | RAB9A (0.40) | HDAC6GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |