SCHEMBL4648255

SCHEMBL4648255

O=S(=O)(O)c1cc(-c2ccsc2)cc2c1OCC2

nearest known ligand 0.34

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
GRIA2 P42262 1/20 0.34
NRP1 O14786 5/20 0.34
ERN1 O75460 3/20 0.33
PPARD Q03181 1/20 0.32
CHEK2 O96017 2/20 0.32
GLO1 Q04760 1/20 0.32
ACMSD Q8TDX5 1/20 0.31
PTPRC P08575 1/20 0.31
PARP1 P09874 1/20 0.31
LOX P28300 1/20 0.31
CYP2A6 P11509 1/20 0.31
GPR84 Q9NQS5 1/20 0.31
CHEK1 O14757 1/20 0.31
PDGFRB P09619 1/20 0.31
PDGFRA P16234 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4646451 0.78 NRP1 (0.33) NRP1ERN1PARP1CYP2A6
SCHEMBL4645575 0.78 MAPT (0.38) NRP1ERN1PARP1
SCHEMBL4648553 0.78 PARP1 (0.41) NRP1ERN1PARP1
SCHEMBL4647459 0.78 PARP1 (0.34) NRP1PARP1
SCHEMBL4648162 0.77 NRP1 (0.40) NRP1PARP1
SCHEMBL4736511 0.77 ACMSD (0.50) CHEK2GLO1ACMSDPARP1CHEK1
SCHEMBL4647930 0.76 PDE4B (0.40) NRP1PARP1
SCHEMBL4648583 0.75 ERN1 (0.40) ERN1CYP2A6
SCHEMBL4647763 0.75 HSD17B1 (0.37) NRP1PARP1
SCHEMBL4648578 0.75 KIF11 (0.39)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080255117-A1 SULFONYLTRYPTOPHANOLS BAYER SCHERING PHARMA AG (DE) 2008-10-16 US claimed
WO-2008104597-A2 SULFONYLTRYPTOPHANOLS BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2008-09-04 WO claimed
EP-1964834-A1 Sulphonyltryptophanols Bayer Schering Pharma Aktiengesellschaft (DE) 2008-09-03 EP claimed
US-20080255117-A1 SULFONYLTRYPTOPHANOLS BAYER SCHERING PHARMA AG (DE) 2008-10-16 US disclosed
WO-2008104597-A2 SULFONYLTRYPTOPHANOLS BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2008-09-04 WO disclosed
EP-1964834-A1 Sulphonyltryptophanols Bayer Schering Pharma Aktiengesellschaft (DE) 2008-09-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080255117-A1 SULFONYLTRYPTOPHANOLS FSHR, NPY1R, GNRHR GRIA2 1038/4885NRP1 2591/4885ERN1 4042/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.