Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.54 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.54 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.54 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4650040 | 0.88 | KDM4E (0.46) | KDM4EGABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL1022143 | 0.84 | GABRA1 (0.61) | KDM4EGABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL4650642 | 0.82 | KDM4E (0.72) | KDM4EGABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL4650021 | 0.81 | KDM4E (0.54) | KDM4EGABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL2971723 | 0.80 | KDM4E (0.56) | KDM4EHTTMEN1CYP1A2POLB | |
| SCHEMBL4451135 | 0.80 | GABRA1 (0.75) | KDM4EGABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL2969124 | 0.80 | KDM4E (0.56) | KDM4EHTTMEN1CYP1A2POLB | |
| SCHEMBL30898566 | 0.79 | GABRA1 (0.70) | GABRA1GABRB2GABRB1GABRA3MEN1 | |
| SCHEMBL29223625 | 0.79 | GABRA1 (0.70) | GABRA1GABRB2GABRB1GABRA3MEN1 | |
| SCHEMBL17338615 | 0.79 | GABRA1 (0.61) | KDM4EGABRA1GABRB2GABRB1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck & Co., Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007067489-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK & CO., INC. (US) | 2007-06-14 | — | — | WO | disclosed |