Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTR1E | P28566 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | SHBG | P04278 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27294725 | 0.89 | IDH1 (0.43) | TSHRTDP1PGRLMNAMEN1 | |
| SCHEMBL11461587 | 0.80 | PGR (0.46) | TSHRTDP1PGRNPC1LMNA | |
| SCHEMBL1060072 | 0.74 | TDP1 (0.41) | TSHRTDP1NPC1LMNAMEN1 | |
| SCHEMBL7368092 | 0.73 | METAP2 (0.48) | TSHRTDP1TEAD4LMNAMEN1 | |
| SCHEMBL10709950 | 0.73 | TDP1 (0.43) | TSHRTDP1TEAD4LMNAMEN1 | |
| SCHEMBL30537465 | 0.71 | CA1 (0.58) | TDP1TEAD4LMNAMEN1MAPT | |
| SCHEMBL11462135 | 0.71 | PGR (0.47) | TSHRPGRNPC1MEN1KMT2A | |
| SCHEMBL28891987 | 0.71 | TSHR (0.64) | TSHRTDP1LMNAMEN1MAPT | |
| SCHEMBL1864078 | 0.71 | SHBG (0.54) | LMNAMAPTSHBGEPHX2EPHX1 | |
| SCHEMBL26404681 | 0.71 | SHBG (0.54) | LMNAMAPTSHBGEPHX2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904047-A2 | APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007008627-A2 | APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2007-01-18 | — | — | WO | disclosed |