Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.48 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HTR1E | P28566 | 1/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10709950 | 0.77 | TDP1 (0.43) | METAP2IDO1TDP1MEN1KMT2A | |
| SCHEMBL30537465 | 0.76 | CA1 (0.58) | IDO1TDP1MEN1KMT2ALMNA | |
| SCHEMBL29050442 | 0.74 | ALDH1A1 (0.53) | METAP2IDO1TDP1MEN1KMT2A | |
| SCHEMBL4649302 | 0.73 | TSHR (0.46) | METAP2TDP1MEN1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL30080220 | 0.72 | METAP2 (0.45) | METAP2TDP1EPHX1EPHX2METAP1 | |
| SCHEMBL14425907 | 0.71 | TDP1 (0.56) | TDP1MEN1KMT2ALMNAMAPT | |
| Hydrochloric Acid SCHEMBL27150944 | 0.70 | HTR1E (0.63) | METAP2MEN1KMT2ALMNAMAPT | |
| SCHEMBL11242555 | 0.70 | RAB9A (0.51) | METAP2MEN1KMT2AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL27150943 | 0.70 | HTR1E (0.63) | METAP2MEN1KMT2ALMNAMAPT | |
| SCHEMBL24741625 | 0.69 | IDO1 (0.58) | METAP2IDO1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752981-B1 | SUBSTITUTED CYCLOPENTYLAMINE DERIVATIVES AND THEIR USE AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-06-09 | — | — | EP | disclosed |
| US-5817698-A | Substituted cycloalkylamine derivatives and their use as calcium channel antagonists | SMITHKLINE BEECHAM PLC (GB) | 1998-10-06 | — | — | US | disclosed |
| EP-0752981-A1 | SUBSTITUTED CYCLOALKYLAMINE DERIVATIVES AND THEIR USE AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-01-15 | — | — | EP | disclosed |
| WO-1995026327-A1 | SUBSTITUTED CYCLOALKYLAMINE DERIVATIVES AND THEIR USE AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-05 | — | — | WO | disclosed |
| EP-0105146-B1 | PROCESS FOR PREPARATION OF DIAMINES OR MIXTURES OF DIAMINES | BAYER AG (DE) | 1985-12-18 | — | — | EP | disclosed |
| EP-0104396-B1 | PROCESS FOR PREPARATION OF DIAMINES OR MIXTURES OF DIAMINES | BAYER AG (DE) | 1985-11-13 | — | — | EP | disclosed |
| EP-0105146-A1 | Process for preparation of diamines or mixtures of diamines | BAYER AG (DE) | 1984-04-11 | — | — | EP | disclosed |
| EP-0105146-A1 | Process for preparation of diamines or mixtures of diamines | BAYER AG (DE) | 1984-04-11 | — | — | EP | disclosed |
| EP-0104396-A1 | Process for preparation of diamines or mixtures of diamines | BAYER AG (DE) | 1984-04-04 | — | — | EP | disclosed |
| EP-0104396-A1 | Process for preparation of diamines or mixtures of diamines | BAYER AG (DE) | 1984-04-04 | — | — | EP | disclosed |