Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 19/20 | 0.72 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.72 |
| ▸ | PDE4A | P27815 | 12/20 | 0.72 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19155555 | 1.00 | PDE4D (0.72) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL6725922 | 1.00 | PDE4D (0.72) | PDE4DPDE4BPDE4APDE4C | |
| Hydrochloric Acid SCHEMBL4013065 | 0.99 | PDE4D (0.71) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL6027642 | 0.90 | PDE4D (0.74) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL4010319 | 0.88 | PDE4D (0.65) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL2889194 | 0.88 | PDE4D (0.68) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL6467291 | 0.87 | PDE4D (0.74) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL2886831 | 0.87 | PDE4D (0.74) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7061325 | 0.87 | PDE4D (0.62) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL2887475 | 0.87 | PDE4D (0.62) | PDE4DPDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150119399-A1 | BETA-CELL REPLICATION PROMOTING COMPOUNDS AND METHODS OF THEIR USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2015-04-30 | — | — | US | claimed |
| EP-2804603-A1 | BETA-CELL REPLICATION PROMOTING COMPOUNDS AND METHODS OF THEIR USE | President and Fellows of Harvard College (US) | 2014-11-26 | — | — | EP | claimed |
| WO-2013106547-A1 | BETA-CELL REPLICATION PROMOTING COMPOUNDS AND METHODS OF THEIR USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-07-18 | — | — | WO | claimed |
| WO-2012025415-A3 | SENSOR FOR INTRAOCULAR PRESSURE | IMPLANDATA OPHTHALMIC PRODUCTS GMBH (DE) | 2012-05-10 | — | — | WO | claimed |
| EP-2040707-B1 | COMBINATION OF ATORVASTATIN WITH A PHOSPHODIESTERASE 4 INHIBITOR FOR THE TREATMENT OF INFLAMMATORY PULMONARY DISEASES | NYCOMED GMBH (DE) | 2011-11-30 | — | — | EP | claimed |
| US-20100069392-A1 | Combination of HMG-COA Reductase Inhibitors with Phosphodiesterase 4 Inhibitors for the Treatment of Inflammatory Pulmonary Disease | NYCOMED GMBH (DE) | 2010-03-18 | — | — | US | claimed |
| US-7531540-B2 | Phthalazinone-piperidino-derivatives as PDE4 inhibitors | NYCOMED GMBH (DE) | 2009-05-12 | — | — | US | claimed |
| US-20070129373-A1 | Phthalazinone-piperidino-derivatives as PDE4 inhibitors | ALTANA PHARMA AG | 2007-06-07 | — | — | US | claimed |
| US-7179810-B2 | Such as 2-{4-[(4aS,8aR)-4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,8,8a-tetrahydro-1H-phthalazin-2-yl]-piperidin-1-yl}-2H-acetamide; phosphodiesterase inhibitors; for treatment of respiratory disorders | ALTANA PHARMA AG (DE) | 2007-02-20 | — | — | US | claimed |
| JP-2006528229-A | — | — | 2006-12-14 | — | — | JP | claimed |
| US-6953853-B2 | Phospholipase inhbitors; antiinflammatory agents; respiratory system disorders | ALTANA PHARMA AG (DE) | 2005-10-11 | — | — | US | claimed |
| US-20050112069-A1 | Pharmaceutical composition of a pde4 or pde 3/4 inhibitor and histamine receptor antagonist | NYCOMED GMBH (DE) | 2005-05-26 | — | — | US | claimed |
| WO-2005023253-A1 | USE OF PDE4 INHIBITORS FOR THE TREATMENT OF DIABETES MELLITUS | ALTANA PHARMA AG (DE) | 2005-03-17 | — | — | WO | claimed |
| WO-2004103407-A2 | COMPOSITION COMPRISING A PDE4 INHIBITOR AND A PDE5 INHIBITOR | ALTANA PHARMA AG (DE) | 2004-12-02 | — | — | WO | claimed |
| WO-2004098633-A1 | COMPOSITION COMPRISING A PDE-4 INHIBITOR AND A TNF ALPHA ANTAGONIST | ALTANA PHARMA AG (DE) | 2004-11-18 | — | — | WO | claimed |
| WO-2004098606-A1 | COMPOSITION COMPRISING A PDE4 INHIBITOR AND SHUIL-1R II | ALTANA PHARMA AG (DE) | 2004-11-18 | — | — | WO | claimed |
| WO-2004098578-A2 | COMPOSITION COMPRISING A PDE4 INHIBITOR AND A TNF-ALFA ANTAGONIST SELECTED FROM INFLIXIMAB, ADALIMUMAB, CDP870 AND CDP517 | ALTANA PHARMA AG (DE) | 2004-11-18 | — | — | WO | claimed |
| US-20040067946-A1 | Phthalatyinone-piperidino-derivatives as pde4 inhibitors | TAKEDA GMBH (DE) | 2004-04-08 | — | — | US | claimed |
| EP-1362044-A1 | PHTHALAZINONE-PIPERIDINO-DERIVATIVES AS PDE4 INHIBITORS | ALTANA Pharma AG (DE) | 2003-11-19 | — | — | EP | claimed |
| WO-2002064584-A1 | PHTHALAYINONE-PIPERIDINO-DERIVATIVES AS PDE4 INHIBITORS | ALTANA PHARMA AG (DE) | 2002-08-22 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040067946-A1 | Phthalatyinone-piperidino-derivatives as pde4 inhibitors | PDE4A, PDE4B, PDE5A | PDE4D 9/4885PDE4B 2/4885PDE4A 1/4885 |
| US-20150119399-A1 | BETA-CELL REPLICATION PROMOTING COMPOUNDS AND METHODS OF THEIR USE | IAPP, GPR119, PCNA | PDE4D 1307/4885PDE4B 1204/4885PDE4A 1173/4885 |
| US-20070129373-A1 | Phthalazinone-piperidino-derivatives as PDE4 inhibitors | PDE4A, PDE4B, PDE5A | PDE4D 6/4885PDE4B 2/4885PDE4A 1/4885 |
| US-20100069392-A1 | Combination of HMG-COA Reductase Inhibitors with Phosphodiesterase 4 Inhibitors for the Treatment of Inflammatory Pulmonary Disease | HMGCR, HMGB3, PDE4A | PDE4D 29/4885PDE4B 6/4885PDE4A 3/4885 |
| US-20050112069-A1 | Pharmaceutical composition of a pde4 or pde 3/4 inhibitor and histamine receptor antagonist | HRH4, PDE4A, PDE4B | PDE4D 9/4885PDE4B 3/4885PDE4A 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.