Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.48 |
| ▸ | CSNK2B | P67870 | 4/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.38 |
| ▸ | MDH2 | P40926 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.36 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4649289 | 0.91 | ALDH1A1 (0.53) | ALDH1A1CYP1A2HPGDMEN1ALOX12 | |
| SCHEMBL4650802 | 0.85 | ALDH1A1 (0.53) | ALDH1A1CYP1A2HPGDMEN1ALOX12 | |
| SCHEMBL4650127 | 0.83 | KDM4A (0.48) | ALDH1A1CYP1A2HPGDMEN1ALOX12 | |
| SCHEMBL4650022 | 0.82 | ALDH1A1 (0.50) | ALDH1A1CYP1A2HPGDMEN1ALOX12 | |
| SCHEMBL4650015 | 0.81 | ALDH1A1 (0.42) | ALDH1A1CYP1A2HPGDMEN1ALOX12 | |
| SCHEMBL4789294 | 0.80 | ALDH1A1 (0.46) | ALDH1A1CYP1A2HPGDMEN1ALOX12 | |
| SCHEMBL4649260 | 0.80 | RAB9A (0.42) | ALDH1A1CYP1A2HPGDMEN1ALOX12 | |
| SCHEMBL4650636 | 0.79 | KDM4E (0.43) | ALDH1A1CYP1A2HPGDMEN1ALOX12 | |
| SCHEMBL4650868 | 0.78 | KDM4E (0.51) | ALDH1A1CYP1A2HPGDMEN1ALOX12 | |
| SCHEMBL4649215 | 0.78 | KDM4E (0.51) | ALDH1A1CYP1A2HPGDMEN1ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck & Co., Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007067489-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK & CO., INC. (US) | 2007-06-14 | — | — | WO | claimed |
| EP-1963271-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck & Co., Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007067489-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK & CO., INC. (US) | 2007-06-14 | — | — | WO | disclosed |