SCHEMBL4649731

SCHEMBL4649731

O=C1NN=C(c2ccc(Br)cc2)CO1

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PDE3B Q13370 20/20 0.59
PDE3A Q14432 20/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4693648 0.83 PDE3B (0.70) PDE3BPDE3A
SCHEMBL7976918 0.83 PDE3B (0.70) PDE3BPDE3A
SCHEMBL261632 0.83 PDE3A (0.65) PDE3BPDE3A
SCHEMBL251865 0.82 PDE3B (0.67) PDE3BPDE3A
SCHEMBL9669173 0.79 PDE3B (0.52) PDE3BPDE3A
SCHEMBL20702701 0.79 PDE3B (0.86) PDE3BPDE3A
SCHEMBL7979367 0.78 PDE3B (0.51) PDE3BPDE3A
SCHEMBL11248109 0.76 PDE3B (0.50) PDE3BPDE3A
SCHEMBL7976944 0.75 PDE3B (0.51) PDE3BPDE3A
SCHEMBL20702677 0.75 PDE3A (0.75) PDE3BPDE3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1963432-A1 EXPANDED AND EXPANDABLE HIGH GLASS TRANSITION TEMPERATURE POLYMERS General Electric Company (US) 2008-09-03 EP disclosed
WO-2007078737-A1 EXPANDED AND EXPANDABLE HIGH GLASS TRANSITION TEMPERATURE POLYMERS GENERAL ELECTRIC COMPANY (US) 2007-07-12 WO disclosed
US-20070149629-A1 Expanded and expandable high glass transition temperature polymers CITIBANK, N.A., AS COLLATERAL AGENT 2007-06-28 US disclosed
EP-0181000-A2 Foamable polyetherimide resin formulation GENERAL ELECTRIC COMPANY (US) 1986-05-14 EP disclosed
US-4543368-A DIHYDRODIAZINONE BLOWING AGENT GENERAL ELECTRIC COMPANY (US) 1985-09-24 US disclosed
US-4334030-A INJECTION MOLDABLE CONCENTRATES CONTAINING AMIDE DERIVATIVES OF AZODICARBOXYLIC ACID AND A DIHYDROOXADIAZINONE AS BLOWING AGENTS GENERAL ELECTRIC COMPANY (US) 1982-06-08 US disclosed
US-4163037-A USING A DIHYDROOXADIAZINONE BLOWING AGENT, INJECTION MOLDING GENERAL ELECTRIC COMPANY (US) 1979-07-31 US disclosed
US-4160088-A HALOGENATION OF KETONE, ALKANOL, HYDROLYSIS GENERAL ELECTRIC COMPANY (US) 1979-07-03 US disclosed
US-4158094-A BLOWING AGENTS GENERAL ELECTRIC COMPANY (US) 1979-06-12 US disclosed
US-4097671-A 5-PHENYL-3,6-DIHYDRO-1,3,4-OXADIAZIN-2-ONE, THERMOPLASTIC POLYMER BLOWING AGENT GENERAL ELECTRIC COMPANY (US) 1978-06-27 US disclosed
US-4097425-A POLYCARBONATES, POLYESTERS, SUBSTITUTED 3,6-DIHYDRO-1,3,4-OXDIAZIN-2-ONE GENERAL ELECTRIC COMPANY (US) 1978-06-27 US disclosed