Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 10/20 | 0.37 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4650258 | 0.97 | CNR2 (0.33) | CNR2 | |
| SCHEMBL4649736 | 0.83 | CDK4 (0.38) | CNR2SCN1ASCN5ASCN8ACYP2D6 | |
| SCHEMBL4649071 | 0.83 | CNR2 (0.37) | CNR2SCN1ASCN5ASCN8AKCNH2 | |
| SCHEMBL4649631 | 0.82 | CNR2 (0.56) | CNR2KDM4ECDK5 | |
| SCHEMBL4649775 | 0.82 | CNR2 (0.40) | CNR2MEN1KMT2ACYP2D6CYP3A4 | |
| SCHEMBL4649781 | 0.79 | CNR2 (0.46) | CNR2CYP2D6KCNH2CYP3A4 | |
| SCHEMBL4648963 | 0.78 | KDM4E (0.46) | CNR2MEN1KMT2ALMNAHTT | |
| SCHEMBL4649712 | 0.78 | CNR2 (0.54) | CNR2SCN1ASCN5ASCN8ASLC6A2 | |
| SCHEMBL4649624 | 0.77 | CNR2 (0.42) | CNR2MEN1KMT2ACYP2D6LMNA | |
| SCHEMBL4649692 | 0.77 | CNR2 (0.50) | CNR2CYP2D6LMNACYP3A4CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718613-B1 | PYRIDINE DERIVATIVES AND THEIR USE AS CB2 RECEPTOR MODULATORS | GLAXO GROUP LTD (GB) | 2008-09-03 | — | — | EP | disclosed |