Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.37 |
| ▸ | CTRC | Q99895 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | LDHB | P07195 | 1/20 | 0.35 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7904072 | 0.85 | BCL2 (0.45) | BCL2BCL2L1HTR2AALDH1A1ALOX15 | |
| SCHEMBL31402366 | 0.82 | BCL2 (0.42) | BCL2BCL2L1HTR2AALDH1A1ALOX15 | |
| SCHEMBL28493010 | 0.82 | BCL2 (0.42) | BCL2BCL2L1HTR2AALDH1A1ALOX15 | |
| SCHEMBL10886157 | 0.79 | BCL2 (0.42) | BCL2BCL2L1HTR2AALDH1A1ALOX15 | |
| SCHEMBL9494600 | 0.77 | BCL2 (0.44) | BCL2BCL2L1HTR2AALDH1A1ALOX15 | |
| SCHEMBL29454271 | 0.77 | BCL2 (0.44) | BCL2BCL2L1HTR2ACALM1ALOX5 | |
| SCHEMBL22232131 | 0.77 | BCL2 (0.44) | BCL2BCL2L1HTR2ACALM1ALOX5 | |
| SCHEMBL20159665 | 0.77 | ALDH1A1 (0.55) | BCL2BCL2L1HTR2AALDH1A1CYP1A2 | |
| SCHEMBL22188467 | 0.75 | BCL2 (0.42) | BCL2BCL2L1HTR2AALDH1A1ALOX15 | |
| SCHEMBL4650255 | 0.74 | HTR2A (0.42) | BCL2BCL2L1HTR2ACALM1CTRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966138-A2 | SUBSTITUTED TRICYCLIC PIPERIDONE DERIVATIVES | Grünenthal GmbH (DE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007079929-A2 | SUBSTITUTED TRICYCLIC PIPERIDONE DERIVATIVES | Grünenthal GmbH (DE) | 2007-07-19 | — | — | WO | disclosed |