SCHEMBL4649989

SCHEMBL4649989

O=c1cc(-c2ccc(Cl)cc2)oc2c(Cl)cc(Cl)cc12

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CSNK2A2 P19784 5/20 0.62
CSNK2B P67870 5/20 0.62
CSNK2A1 P68400 5/20 0.62
CYP1A1 P04798 3/20 0.59
CYP1A2 P05177 3/20 0.59
CYP1B1 Q16678 3/20 0.59
TNKS O95271 2/20 0.56
CDK1 P06493 2/20 0.56
CCNB1 P14635 2/20 0.56
GABRP O00591 3/20 0.52
GABRD O14764 3/20 0.52
GABRA1 P14867 3/20 0.52
GABRB1 P18505 3/20 0.52
GABRG2 P18507 3/20 0.52
GABRB3 P28472 3/20 0.52
GABRA5 P31644 3/20 0.52
GABRA3 P34903 3/20 0.52
GABRA2 P47869 3/20 0.52
GABRB2 P47870 3/20 0.52
GABRA4 P48169 3/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15231415 0.89 CSNK2A2 (0.65) CSNK2A2CSNK2BCSNK2A1CYP1A1CYP1A2
SCHEMBL4925702 0.89 CSNK2A2 (0.62) CSNK2A2CSNK2BCSNK2A1CYP1A1CYP1A2
SCHEMBL4649950 0.89 TNKS (0.61) CSNK2A2CSNK2BCSNK2A1CYP1A1CYP1A2
SCHEMBL24046919 0.80 CSNK2A2 (0.50) CSNK2A2CSNK2BCSNK2A1CYP1A1CYP1A2
SCHEMBL24046751 0.78 CSNK2A2 (0.67) CSNK2A2CSNK2BCSNK2A1CYP1A1CYP1A2
SCHEMBL4649432 0.77 CSNK2A2 (0.58) CSNK2A2CSNK2BCSNK2A1CYP1A1CYP1A2
SCHEMBL4650588 0.77 GABRP (0.82) CSNK2A2CSNK2BCSNK2A1TNKSGABRP
SCHEMBL21801314 0.75 CSNK2A2 (0.56) CSNK2A2CSNK2BCSNK2A1CYP1A1CYP1A2
SCHEMBL7117856 0.73 TP53 (0.44) CSNK2A2CSNK2BCSNK2A1
SCHEMBL21959063 0.73 CSNK2A2 (0.48) CSNK2A2CSNK2BCSNK2A1CYP1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6872771-B1 Tire with rubber containing flavone THE GOODYEAR TIRE & RUBBER COMPANY (US) 2005-03-29 US claimed
EP-2730431-B1 Rubber composition and tire with rubber containing flavone GOODYEAR TIRE & RUBBER (US) 2017-06-28 EP disclosed
US-20140135433-A1 TIRE WITH RUBBER CONTAINING FLAVONE THE GOODYEAR TIRE & RUBBER COMPANY (US) 2014-05-15 US disclosed
EP-2730431-A1 Rubber composition and tire with rubber containing flavone The Goodyear Tire & Rubber Company (US) 2014-05-14 EP disclosed
EP-1391327-B1 Tire with rubber containing flavone GOODYEAR TIRE & RUBBER (US) 2008-09-03 EP disclosed
US-6872771-B1 Tire with rubber containing flavone THE GOODYEAR TIRE & RUBBER COMPANY (US) 2005-03-29 US disclosed
EP-1391327-A1 Tire with rubber containing flavone THE GOODYEAR TIRE & RUBBER COMPANY (US) 2004-02-25 EP disclosed
WO-2003057210-A1 COMPOSITIONS AND METHODS FOR INCREASING CELL PROLIFERATION COMPRISING A FLAVONOID KIMBERLY-CLARK WORLDWIDE, INC. (US) 2003-07-17 WO disclosed
US-20030125264-A1 Methods For Treating Wounds KIMBERLY-CLARK WORLDWIDE, INC. 2003-07-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030125264-A1 Methods For Treating Wounds FGF2, MMP1, FIBP CSNK2A2 3078/4885CSNK2B 2902/4885CSNK2A1 2974/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.