Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | USP1 | O94782 | 1/20 | 0.42 |
| ▸ | USP8 | P40818 | 1/20 | 0.42 |
| ▸ | OTUB1 | Q96FW1 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4650006 | 1.00 | HTR6 (0.44) | HTR6CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL4649412 | 0.95 | CHRM2 (0.45) | HTR6CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL4650745 | 0.95 | HTR6 (0.47) | HTR6CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL4649415 | 0.82 | ROCK1 (0.46) | HTR6CHEK2HTR2AHTR2B | |
| SCHEMBL4649974 | 0.80 | CHRM2 (0.43) | HTR6CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL4649235 | 0.80 | CHRM2 (0.43) | HTR6CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL4650016 | 0.80 | PRKCZ (0.49) | HTR6HTR2A | |
| SCHEMBL4650003 | 0.79 | HTR6 (0.51) | HTR6CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL4756585 | 0.79 | HTR6 (0.51) | HTR6CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL4649908 | 0.79 | HTR6 (0.51) | HTR6CHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730112-B1 | 3-((HETERO)ARYLSULFONYL)-8'[ (AMINOALKYL)OXY]QUINOLINES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LTD (GB) | 2008-09-03 | — | — | EP | claimed |