SCHEMBL4649412

SCHEMBL4649412

CN1CCCC(Oc2ccc3ncc(S(=O)(=O)c4ccccc4)cc3c2)C1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 2/20 0.45
CHRM4 P08173 2/20 0.45
CHRM5 P08912 2/20 0.45
CHRM1 P11229 2/20 0.45
CHRM3 P20309 2/20 0.45
HTR6 P50406 4/20 0.42
ROCK1 Q13464 5/20 0.41
ROCK2 O75116 3/20 0.41
KCNH2 Q12809 1/20 0.40
CES2 O00748 1/20 0.40
CCR2 P41597 1/20 0.40
HDAC3 O15379 1/20 0.40
HDAC4 P56524 1/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC7 Q8WUI4 1/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC10 Q969S8 1/20 0.40
HDAC11 Q96DB2 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4650006 0.95 HTR6 (0.44) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL4650101 0.95 HTR6 (0.44) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL4650745 0.90 HTR6 (0.47) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL4649408 0.80 HTR6 (0.48) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL4650913 0.80 ROCK1 (0.51) HTR6ROCK1ROCK2KCNH2HTR2A
SCHEMBL4649415 0.79 ROCK1 (0.46) HTR6ROCK1ROCK2HTR2AHTR2B
SCHEMBL4649409 0.78 CHRNB2 (0.56)
SCHEMBL4649235 0.78 CHRM2 (0.43) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL4649974 0.78 CHRM2 (0.43) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL4650016 0.78 PRKCZ (0.49) HTR6ROCK1ROCK2KCNH2HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1730112-B1 3-((HETERO)ARYLSULFONYL)-8'[ (AMINOALKYL)OXY]QUINOLINES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS GLAXO GROUP LTD (GB) 2008-09-03 EP claimed