SCHEMBL4650408

SCHEMBL4650408

Nc1cccc(-c2c(Cl)[c]ccc2F)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.40
ALDH1A1 P00352 2/20 0.37
MAP4K4 O95819 3/20 0.37
TAAR1 Q96RJ0 1/20 0.36
CA12 O43570 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA9 Q16790 1/20 0.36
CYP3A4 P08684 4/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C9 P11712 1/20 0.35
HSD17B1 P14061 1/20 0.35
CYP2B6 P20813 1/20 0.35
CYP2C19 P33261 1/20 0.35
HSD17B2 P37059 1/20 0.35
CASP1 P29466 1/20 0.34
RECQL P46063 1/20 0.34
MEN1 O00255 2/20 0.34
PSIP1 O75475 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5182645 0.79 CYP1A2 (0.38) ALDH1A1CYP1A2LMNAMAPT
SCHEMBL6509046 0.77 MAOA (0.54) MAOAALDH1A1MAP4K4TAAR1CA12
SCHEMBL30549059 0.77 MAOA (0.54) MAOAALDH1A1MAP4K4TAAR1CA12
SCHEMBL12480139 0.76 MAOA (0.45) MAOAALDH1A1MAP4K4TAAR1CA12
SCHEMBL5778165 0.75 TYMP (0.34)
SCHEMBL4688554 0.73 PTGS2 (0.38) MCL1
SCHEMBL436848 0.73 NPC1 (0.39) ALDH1A1CYP3A4CYP1A2CYP2D6CYP2C9
SCHEMBL3785823 0.72 MAOA (0.48) MAOAALDH1A1MAP4K4TAAR1CA12
SCHEMBL8264667 0.72 MAOA (0.48) MAOAALDH1A1MAP4K4TAAR1CA12
SCHEMBL1745091 0.72 PTGES (0.35) TAAR1CYP1A2MEN1LMNAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1603909-A4 LINEAR CHAIN SUBSTITUTED MONOCYCLIC AND BICYCLIC DERIVATIVES AS FACTOR XA INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2008-09-03 EP claimed
EP-1603909-A2 LINEAR CHAIN SUBSTITUTED MONOCYCLIC AND BICYCLIC DERIVATIVES AS FACTOR XA INHIBITORS Brystol-Myers Squibb Company (US) 2005-12-14 EP claimed
WO-2004083177-A2 LINEAR CHAIN SUBSTITUTED MONOCYCLIC AND BICYCLIC DERIVATIVES AS FACTOR XA INHIBITORS BRYSTOL-MYERS SQUIBB COMPANY (US) 2004-09-30 WO claimed
EP-1603909-A4 LINEAR CHAIN SUBSTITUTED MONOCYCLIC AND BICYCLIC DERIVATIVES AS FACTOR XA INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2008-09-03 EP disclosed
EP-1603909-A2 LINEAR CHAIN SUBSTITUTED MONOCYCLIC AND BICYCLIC DERIVATIVES AS FACTOR XA INHIBITORS Brystol-Myers Squibb Company (US) 2005-12-14 EP disclosed
WO-2004083177-A2 LINEAR CHAIN SUBSTITUTED MONOCYCLIC AND BICYCLIC DERIVATIVES AS FACTOR XA INHIBITORS BRYSTOL-MYERS SQUIBB COMPANY (US) 2004-09-30 WO disclosed