SCHEMBL4650418

SCHEMBL4650418

CCN=C=NC(CCN(C)C)Cc1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 3/20 0.41
HRH1 P35367 2/20 0.41
TAAR1 Q96RJ0 1/20 0.40
SIGMAR1 Q99720 5/20 0.39
MAOB P27338 2/20 0.38
UBE2N P61088 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP2D6 P10635 1/20 0.37
CHRM1 P11229 1/20 0.36
ADRA2B P18089 2/20 0.35
ADRA2C P18825 2/20 0.35
ADRA1A P35348 2/20 0.35
OPRK1 P41145 2/20 0.35
SLC6A2 P23975 1/20 0.35
SLC6A4 P31645 1/20 0.35
SLC6A3 Q01959 1/20 0.35
KCNH2 Q12809 1/20 0.35
ADRA2A P08913 1/20 0.35
MAOA P21397 1/20 0.35
SNCA P37840 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL888150 0.80 HTR2A (0.44) HTR2AHRH1TAAR1SIGMAR1MAOB
Hydrochloric Acid SCHEMBL7737386 0.73 CYP1A2 (0.50) HTR2AHRH1CYP1A2CYP2D6
SCHEMBL4650416 0.71 OPRK1 (0.39) HTR2AMAOBCYP1A2CYP2D6ADRA2B
SCHEMBL26730248 0.69 HTR2A (0.53) HTR2AHRH1TAAR1SIGMAR1UBE2N
SCHEMBL6205916 0.67 EPHX1 (0.59) HTR2AHRH1TAAR1SIGMAR1UBE2N
Hydrochloric Acid SCHEMBL7284036 0.67 CYP1A2 (0.50) HTR2AHRH1CYP1A2CYP2D6
SCHEMBL10587652 0.67 HTR2A (0.47) HTR2AHRH1TAAR1SIGMAR1MAOB
SCHEMBL11230586 0.66 HTR2A (0.50) HTR2AHRH1TAAR1SIGMAR1UBE2N
SCHEMBL31538222 0.66 CYP1A2 (0.33) HTR2AHRH1CYP1A2CYP2D6
SCHEMBL2766608 0.64 MIF (0.54) SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1968938-A1 SUBSTITUTED PROPIOLIC ACID AMIDES AND THEIR USE FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2008-09-17 EP disclosed
EP-1968963-A1 SUBSTITUTED PROPIOLIC ACID AMIDES AND THEIR USE FOR PRODUCING ANALGESICS Grünenthal GmbH (DE) 2008-09-17 EP disclosed
EP-1968935-A1 SUBSTITUTED BIS(HETERO)AROMATIC N-ETHYLPROPIOLAMIDES AND USE THEREOF FOR PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2008-09-17 EP disclosed
WO-2007079957-A1 SUBSTITUTED PROPIOLIC ACID AMIDES AND THEIR USE FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2007-07-19 WO disclosed
WO-2007079958-A1 SUBSTITUTED BIS(HETERO)AROMATIC N-ETHYLPROPIOLAMIDES AND USE THEREOF FOR PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2007-07-19 WO disclosed
WO-2007079959-A1 SUBSTITUTED PROPIOLIC ACID AMIDES AND THEIR USE FOR PRODUCING ANALGESICS Grünenthal GmbH (DE) 2007-07-19 WO disclosed