Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13592680 | 1.00 | KDM4E (0.54) | KDM4EALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL13380707 | 1.00 | KDM4E (0.54) | KDM4EALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL12938337 | 0.98 | KDM4E (0.50) | KDM4EALDH1A1TDP1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL27492797 | 0.91 | KDM4E (0.48) | KDM4EALDH1A1TDP1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL542557 | 0.89 | ALDH1A1 (0.47) | KDM4EALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL544890 | 0.89 | KDM4E (0.45) | KDM4EALDH1A1TDP1MEN1KMT2A | |
| Water SCHEMBL30365140 | 0.87 | KDM4E (0.44) | KDM4EALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL6878412 | 0.87 | KDM4E (0.44) | KDM4EALDH1A1TDP1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6442683 | 0.86 | ALDH1A1 (0.52) | KDM4EALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL544197 | 0.85 | MAPT (0.47) | KDM4EALDH1A1TDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720824-B1 | SYNTHETIC MULTIPLE QUATERNARY AMMONIUM SALTS | SACHEM INC (US) | 2008-09-24 | — | — | EP | disclosed |
| US-7214806-B2 | Synthetic multiple quaternary ammonium salts | SACHEM, INC. (US) | 2007-05-08 | — | — | US | disclosed |
| US-20050194113-A1 | Synthetic multiple quaternary ammonium salts | SACHEM, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050194113-A1 | Synthetic multiple quaternary ammonium salts | ASH2L, AS3MT, ARGLU1 | KDM4E 851/4885ALDH1A1 3207/4885TDP1 4582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.