Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 16/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.42 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4654417 | 0.92 | CCR2 (0.44) | CCR2PTGER4PTGDRMRGPRX4 | |
| SCHEMBL4649922 | 0.92 | CCR2 (0.46) | CCR2PTGER4PTGDRMRGPRX4 | |
| SCHEMBL4650219 | 0.91 | CCR2 (0.43) | CCR2PTGER4PTGDRMRGPRX4 | |
| SCHEMBL4649957 | 0.87 | CCR2 (0.53) | CCR2PTGER4 | |
| SCHEMBL4649594 | 0.80 | CCR2 (0.48) | CCR2 | |
| SCHEMBL4650663 | 0.77 | CCR2 (0.55) | CCR2PTGER4 | |
| SCHEMBL4650169 | 0.75 | CCR9 (0.55) | CCR2 | |
| SCHEMBL4649066 | 0.73 | CCR2 (0.43) | CCR2PTGER4 | |
| SCHEMBL4650004 | 0.73 | CCR2 (0.54) | CCR2 | |
| SCHEMBL4651957 | 0.72 | CCR2 (0.52) | CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904487-A2 | INDOLE DERIVATIVES FOR THE TREATMENT OF TUBERCULOSIS | AstraZeneca AB (SE) | 2008-04-02 | — | — | EP | disclosed |
| WO-2006067392-A2 | INDOLE DERIVATIVES FOR THE TREATMENT OF TUBERCULOSIS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |