Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 13/20 | 0.54 |
| ▸ | CCR9 | P51686 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4648818 | 0.93 | CCR2 (0.53) | CCR2CCR9MAPTF10 | |
| SCHEMBL4650169 | 0.91 | CCR9 (0.55) | CCR2CCR9 | |
| SCHEMBL4748723 | 0.88 | PTGES (0.51) | CCR2PLA2G2A | |
| SCHEMBL4650663 | 0.87 | CCR2 (0.55) | CCR2CCR9MAPTF10PLA2G2A | |
| SCHEMBL4649957 | 0.86 | CCR2 (0.53) | CCR2CCR9MAPTF10PLA2G2A | |
| SCHEMBL4649909 | 0.84 | CCR2 (0.50) | CCR2MAPTF10 | |
| SCHEMBL4807606 | 0.83 | CCR2 (0.51) | CCR2MAPTF10 | |
| SCHEMBL4653137 | 0.80 | CCR2 (0.47) | CCR2MAPTF10 | |
| SCHEMBL4649594 | 0.79 | CCR2 (0.48) | CCR2MAPTF10 | |
| SCHEMBL4649469 | 0.76 | CCR2 (0.55) | CCR2MAPTF10PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904487-A2 | INDOLE DERIVATIVES FOR THE TREATMENT OF TUBERCULOSIS | AstraZeneca AB (SE) | 2008-04-02 | — | — | EP | disclosed |
| WO-2006067392-A2 | INDOLE DERIVATIVES FOR THE TREATMENT OF TUBERCULOSIS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |