Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 14/20 | 0.55 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CCR9 | P51686 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4649957 | 0.90 | CCR2 (0.53) | CCR2PLA2G2AMAPTCCR9F10 | |
| SCHEMBL4650169 | 0.89 | CCR9 (0.55) | CCR2CCR9 | |
| SCHEMBL4650004 | 0.87 | CCR2 (0.54) | CCR2PLA2G2AMAPTCCR9F10 | |
| SCHEMBL4748723 | 0.87 | PTGES (0.51) | CCR2PLA2G2APTGER4 | |
| SCHEMBL4807606 | 0.86 | CCR2 (0.51) | CCR2MAPTF10PTGER4 | |
| SCHEMBL4649909 | 0.85 | CCR2 (0.50) | CCR2MAPTF10PTGER4 | |
| SCHEMBL4648818 | 0.83 | CCR2 (0.53) | CCR2MAPTCCR9F10 | |
| SCHEMBL4649594 | 0.83 | CCR2 (0.48) | CCR2MAPTF10 | |
| SCHEMBL4653137 | 0.82 | CCR2 (0.47) | CCR2MAPTF10PTGER4 | |
| SCHEMBL4649469 | 0.80 | CCR2 (0.55) | CCR2PLA2G2AMAPTF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948623-A2 | HETEROCYCLIC AMIDE DERIVATIVES AS RXR AGONISTS FOR THE TREATMENT OF DYSLIPIDEMIA, HYPERCHOLESTEROLEMIA AND DIABETES | Janssen Pharmaceutica, N.V. (BE) | 2008-07-30 | — | — | EP | disclosed |
| EP-1904487-A2 | INDOLE DERIVATIVES FOR THE TREATMENT OF TUBERCULOSIS | AstraZeneca AB (SE) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007041077-A2 | HETEROCYCLIC AMIDE DERIVATIVES AS RXR AGONISTS FOR THE TREATMENT OF DYSLIPIDEMIA, HYPERCHOLESTEROLEMIA AND DIABETES | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-04-12 | — | — | WO | disclosed |
| WO-2006067392-A2 | INDOLE DERIVATIVES FOR THE TREATMENT OF TUBERCULOSIS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |